ORCID

https://orcid.org/0009-0005-8237-1335

Date of Award

2025

Document Type

Thesis

Degree Name

MS in Chemistry

Department

Chemistry

First Advisor

David P Brown

Second Advisor

Victor O Cesare

Third Advisor

Anne V Vazquez

Abstract

An optimized approach toward the synthesis of representative coumarin derivatives is described. In addition to standard heat application methods, microwave-assisted coupling has proven beneficial in generating the targeted molecular hybrids which will serve as key templates in the development of new drugs to address resistance and specificity challenges. The coumarin moiety is a fantastic scaffold for molecular hybridization and has gained much warranted attention due to its efficacy in anticancer, antibacterial, and antitumor activity. In this research, novel molecular hybrids of umbelliferone were synthesized and fully characterized as new potential players in the anticancer, antitumor and antibiotic race, as well as the fight against drug resistance. All desired hybrids were analyzed by 1H NMR, 13C NMR and Infrared (IR), sufficiently substantiating expected data. This study further demonstrated the potential of molecular hybridization of coumarin moieties, and adds to the list of novel conjugates with potentially increased pharmacological properties.

Included in

Chemistry Commons

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